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Sunday, October 22, 2017

Arrival
Shuttle from Prague Airport to Chateau Liblice will be provided.

Registration, Welcome Drink

Monday, October 23, 2017

Opening of the Conference

Keynote Lecture

8.30 - 9.10
Petr Svoboda, Prague, Czech Republic - A sobering look at the mammalian RNAi pathway

Session 1

Perspectives from Rodent Models for Neurodegenerative Diseases

9.10 - 9.50
Slaven Erzeg, Valencia, Spain
- Induced pluripotent stem cells for modelling and treatment of human neurodegenerative diseases

9.50 - 10.20
Marian Hruska-Plochan, Zurich, Switzerland
- Interaction of DPRs alter their subcellular localization, aggregation pattern (and toxicity)

10.20 - 10.50
Martin Balaštík, Praha, Czech Republic
- Isomerase Pin1 as a regulator of stability and solubility of CRMP2 in aging and AD.

11.20 - 11.50
Huu Phuc Nhuyen, Tuebingen, Germany
- Effects of lowering huntingtin in the Hypothalamus in the BACHD rat

11.50 - 12.20
Petr Vodicka, Boston, USA / Libechov, Czech Republic
– Stimulating autophagy and reducing inclusions in mouse model of Huntington's disease via expression of transcription factor EB (TFEB)

12.20 - 12.50
Helena Skalnikova, Libechov, Czech Republic
- Exosomes as potential carriers of biomarkers in neurodegenerative diseases

12.50 - 13.20
Marta Biagioli, Italy
- Aberrant Alternative Splicing as a new player in Huntington’s Disease pathogenesis


HD and ALS – Clinical view:

14.30 - 15.00
Jiri Klempir, Prague, Czech Republic
– Living with neurodegeneration


Session 2

Progress in Technologies and Development of Large Animal Models of HD and ALS

15.00 – 15.30
Carsten Bjarkam Alborg, DK
- Cytoarchitecture and surface anatomy of the Göttingen minipig telencephalon

15.30 - 16.00
Owen Lewis, Bristol, UK
- Functional and translational performance of a novel recessed-step catheter and stereotactic system for use in pre-clinical and clinical CED indications

16:00 – 16:30
Bas Blits, Amsterdam, NL
- AAV mediated delivery in large animals

16.30 – 17:00
Martin Marsala, San Diego, USA
- Potent anti-spasticity and anti-nociceptive effect of subpial GAD65 and VGAT delivery in rat and mice

Video conference

17.30 – 18.30
Gene W. Yeo, San Diego, USA
- RNA targeting CRISPR technologies for disease applications

Concert and dance


Tuesday, October 24, 2017

Session 3

Perspectives of Gene Therapy in Neurodegenerative Diseases

8.30 – 9.00
Nik Klymiuk, Munich, Germany
- Gene Editing for Tailoring Pig Models for Monogenic Diseases

9.00 – 9.30
Melvin Evers, Amsterdam, NL
- Establishing proof-of-concept of gene therapy for Huntington’s disease

9.30 – 10.00
Edith L. Pfister, Boston, USA
– Reduction of Huntingtin by an scAAV9 artificial miRNA in large animals

10.00 – 10.20
Petra Vochozkova, Munich, Germany / Libechov, Czech Republic
- Evaluation of strategies for humanization of the entire porcine HTT locus.

Session 4

New DNA Damage and Mitochondria Biomarkers in Development of HD and ALS

13.00 -13.30
Lars Eide, Oslo, Norway
- New DNA Damage and Mitochondria Biomarkers in Development of HD and ALS.

13.30 – 14.00
Hana Hansikova, Prague, Czech Republic
- Mitochondrial phenotype in minipig model transgenic for N-terminal part of human mutated huntingtin

14.00 – 14.20
Petra Šmatlíková, Libechov, Czech Republic
- Oxidative stress in Primary Porcine Fibroblasts Expressing Mutated Huntingtin.

14.20 – 14.50
Petr Šolc, Libechov, Czech Republic
- DNA damage response in the development of Huntington´s disease

14.50 – 15.10
Michaela Vaškovičová, Libechov, Czech Republic
- Double strand DNA breaks response in Huntington´s disease transgenic minipigs

Session 5

Development of New Cognitive and Behavioral Tests in Large Animal Models of HD

15.40 – 16.10
Zdenka Ellederova, Libechov, Czech Republic
- Following the phenotype development of TgHD minipigs by invasive and noninvasive approach.

16.10 – 16.40
Verena Schuldenzucker, Muenster, Germany
- Longitudinal phenotyping of tgHD minipigs

16.40 -17.10
Ralf Reilmann, Muenster, Germany
- The minipig model in Huntington Disease - opportunities and challenges

Closing of the Conference


Wednesday, October 25, 2017

Morning excursion through the PIGMOD Center minipig facility, Pavilion of Surgery unit and Pavilion of Biomedicine will be provided.