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Sunday, October 22, 2017
ArrivalShuttle from Prague Airport to Chateau Liblice will be provided.
Registration, Welcome Drink
Monday, October 23, 2017
Opening of the Conference
Keynote Lecture
8.30 - 9.10Petr Svoboda, Prague, Czech Republic - A sobering look at the mammalian RNAi pathway
Session 1
Perspectives from Rodent Models for Neurodegenerative Diseases
9.10 - 9.50
Slaven Erzeg, Valencia, Spain - Induced pluripotent stem cells for modelling and treatment of human neurodegenerative diseases
9.50 - 10.20
Marian Hruska-Plochan, Zurich, Switzerland - Interaction of DPRs alter their subcellular localization, aggregation pattern (and toxicity)
10.20 - 10.50
Martin Balaštík, Praha, Czech Republic - Isomerase Pin1 as a regulator of stability and solubility of CRMP2 in aging and AD.
11.20 - 11.50
Huu Phuc Nhuyen, Tuebingen, Germany - Effects of lowering huntingtin in the Hypothalamus in the BACHD rat
11.50 - 12.20
Petr Vodicka, Boston, USA / Libechov, Czech Republic – Stimulating autophagy and reducing inclusions in mouse model of Huntington's disease via expression of transcription factor EB (TFEB)
12.20 - 12.50
Helena Skalnikova, Libechov, Czech Republic - Exosomes as potential carriers of biomarkers in neurodegenerative diseases
12.50 - 13.20
Marta Biagioli, Italy - Aberrant Alternative Splicing as a new player in Huntington’s Disease pathogenesis
HD and ALS – Clinical view:
14.30 - 15.00
Jiri Klempir, Prague, Czech Republic – Living with neurodegeneration
Session 2
Progress in Technologies and Development of Large Animal Models of HD and ALS
15.00 – 15.30
Carsten Bjarkam Alborg, DK - Cytoarchitecture and surface anatomy of the Göttingen minipig telencephalon
15.30 - 16.00
Owen Lewis, Bristol, UK - Functional and translational performance of a novel recessed-step catheter and stereotactic system for use in pre-clinical and clinical CED indications
16:00 – 16:30
Bas Blits, Amsterdam, NL - AAV mediated delivery in large animals
16.30 – 17:00
Martin Marsala, San Diego, USA - Potent anti-spasticity and anti-nociceptive effect of subpial GAD65 and VGAT delivery in rat and mice
Video conference
17.30 – 18.30
Gene W. Yeo, San Diego, USA - RNA targeting CRISPR technologies for disease applications
Concert and dance
Tuesday, October 24, 2017
Session 3
Perspectives of Gene Therapy in Neurodegenerative Diseases
8.30 – 9.00
Nik Klymiuk, Munich, Germany - Gene Editing for Tailoring Pig Models for Monogenic Diseases
9.00 – 9.30
Melvin Evers, Amsterdam, NL - Establishing proof-of-concept of gene therapy for Huntington’s disease
9.30 – 10.00
Edith L. Pfister, Boston, USA – Reduction of Huntingtin by an scAAV9 artificial miRNA in large animals
10.00 – 10.20
Petra Vochozkova, Munich, Germany / Libechov, Czech Republic - Evaluation of strategies for humanization of the entire porcine HTT locus.
Session 4
New DNA Damage and Mitochondria Biomarkers in Development of HD and ALS
13.00 -13.30
Lars Eide, Oslo, Norway - New DNA Damage and Mitochondria Biomarkers in Development of HD and ALS.
13.30 – 14.00
Hana Hansikova, Prague, Czech Republic - Mitochondrial phenotype in minipig model transgenic for N-terminal part of human mutated huntingtin
14.00 – 14.20
Petra Šmatlíková, Libechov, Czech Republic - Oxidative stress in Primary Porcine Fibroblasts Expressing Mutated Huntingtin.
14.20 – 14.50
Petr Šolc, Libechov, Czech Republic - DNA damage response in the development of Huntington´s disease
14.50 – 15.10
Michaela Vaškovičová, Libechov, Czech Republic - Double strand DNA breaks response in Huntington´s disease transgenic minipigs
Session 5
Development of New Cognitive and Behavioral Tests in Large Animal Models of HD
15.40 – 16.10
Zdenka Ellederova, Libechov, Czech Republic - Following the phenotype development of TgHD minipigs by invasive and noninvasive approach.
16.10 – 16.40
Verena Schuldenzucker, Muenster, Germany - Longitudinal phenotyping of tgHD minipigs
16.40 -17.10
Ralf Reilmann, Muenster, Germany - The minipig model in Huntington Disease - opportunities and challenges
Closing of the Conference
Wednesday, October 25, 2017
Morning excursion through the PIGMOD Center minipig facility, Pavilion of Surgery unit and Pavilion of Biomedicine will be provided.